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. 1984 Jan 28;288(6413):268-70.
doi: 10.1136/bmj.288.6413.268.

Erythrocyte choline concentrations and cluster headache

J de Belleroche, G E Cook, I Das, R Joseph, I Tresidder, S Rouse, R Petty, F C Clifford Rose

Erythrocyte choline concentrations and cluster headache

J de Belleroche et al. Br Med J (Clin Res Ed). .

Abstract

Erythrocyte choline concentrations were measured in patients with cluster headache and age related control subjects. Concentrations were significantly reduced in the patients with headache both during a cluster period and between clusters, being 58% and 55% of the control value, respectively. After two weeks' treatment with lithium, choline concentrations in the patients with cluster headache increased to 78 times the control value (mean 369.2 mumol/l (3840 micrograms/100 ml) compared with 4.7 mumol/l (49 micrograms/100 ml]. The presence of depressed erythrocyte choline concentrations during and between cluster attacks indicates that this may be a predisposing condition which results in a cluster attack only when associated with a trigger factor.

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