doi: 10.1016/0006-8993(84)90752-2.
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat
- PMID: 6419985
- DOI: 10.1016/0006-8993(84)90752-2
Item in Clipboard
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat
Brain Res.
.
Abstract
Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.
Similar articles
-
Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat.J Chromatogr. 1983 Oct 14;277:201-8. doi: 10.1016/s0378-4347(00)84837-9. J Chromatogr. 1983. PMID: 6643606
-
Flunitrazepam and lormetazepam do not affect the pharmacokinetics of the benzodiazepine antagonist Ro 15-1788.Br J Clin Pharmacol. 1985 Jan;19(1):95-8. doi: 10.1111/j.1365-2125.1985.tb02619.x. Br J Clin Pharmacol. 1985. PMID: 3919752 Free PMC article. Clinical Trial.
-
[The action of the benzodiazepine antagonist Ro 15-1788].Anaesthesist. 1984 Aug;33(8):343-7. Anaesthesist. 1984. PMID: 6148904 German.
-
Determination of Ro 15-1788, a benzodiazepine antagonist, in human plasma by gas-liquid chromatography with nitrogen-phosphorus detection. Application to single-dose pharmacokinetic studies.Pharmacology. 1983;26(5):285-9. doi: 10.1159/000137812. Pharmacology. 1983. PMID: 6407037
-
Determinants of pharmacologic effects and toxicity of benzodiazepine hypnotics: role of lipophilicity and plasma elimination rates.J Clin Psychiatry. 1991 Sep;52 Suppl:11-4. J Clin Psychiatry. 1991. PMID: 1654317 Review.
Cited by
-
Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties.Psychopharmacology (Berl). 1986;89(1):113-7. doi: 10.1007/BF00175201. Psychopharmacology (Berl). 1986. PMID: 3090585
-
Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil).Psychopharmacology (Berl). 1994 Jul;115(3):332-9. doi: 10.1007/BF02245074. Psychopharmacology (Berl). 1994. PMID: 7871073
-
Quantitative pharmacological analyses of the interaction between flumazenil and midazolam in monkeys discriminating midazolam: Determination of the functional half life of flumazenil.Eur J Pharmacol. 2014 Jan 15;723:405-9. doi: 10.1016/j.ejphar.2013.10.065. Epub 2013 Nov 8. Eur J Pharmacol. 2014. PMID: 24216249 Free PMC article.
-
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.Psychopharmacology (Berl). 1984;82(3):199-202. doi: 10.1007/BF00427773. Psychopharmacology (Berl). 1984. PMID: 6326177
-
Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands.Alcohol Clin Exp Res. 2005 Apr;29(4):553-63. doi: 10.1097/01.alc.0000158840.07475.97. Alcohol Clin Exp Res. 2005. PMID: 15834220 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
