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. 1984 Feb;307(5950):417-22.
doi: 10.1038/307417a0.

The molecular biology of immunoglobulin D

F R Blattner, P W Tucker

The molecular biology of immunoglobulin D

F R Blattner et al. Nature. 1984 Feb.

Abstract

Immunoglobulin D (IgD) is co-expressed with immunoglobulin M (IgM) on the membranes of most B cells, yet its biological function has remained a mystery. Recent detailed information on the structure and transcription of the unusual IgD heavy chain (delta) gene in mouse suggests a complex genetic control. A model is presented for the developmental regulation of IgM and IgD and roles suggested for the membrane and secreted forms of IgD in the immune network.

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