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. 1978 Mar;25(3):806-10.
doi: 10.1128/JVI.25.3.806-810.1978.

Evidence from UV transcription mapping that late adenovirus type 2 mRNA is derived from a large precursor molecule

S Goldberg, J Nevins, J E Darnell

Evidence from UV transcription mapping that late adenovirus type 2 mRNA is derived from a large precursor molecule

S Goldberg et al. J Virol. 1978 Mar.

Abstract

The UV inactivation of labeling of various late adenovirus type 2 mRNA's is as great or greater than the inactivation of labeling of the same sequences that are present in a large primary RNA transcript in the cell nucleus. Thus, the large nuclear adenovirus type 2-specific RNA appears to be the obligatory precursor of cytoplasmic mRNA. The majority of the mRNA's derived from the large precursor apparently require the synthesis of the whole nuclear molecule. A UV-sensitive target necessary for proper processing of all the mRNA's may exist near the end of the transcription unit.

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References

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