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. 1984 Feb 10;223(4636):607-9.
doi: 10.1126/science.6420888.

Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft

H Lau, K Reemtsma, M A Hardy

Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft

H Lau et al. Science. .

Abstract

Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.

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