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. 1984;46(2):102-6.
doi: 10.1111/j.1423-0410.1984.tb00059.x.

HLA-ABC and DR antigens in celiac disease. A study in a pediatric Italian population

S Trabace, A Giunta, M Rosso, D Marzorati, I Cascino, A Tettamanti, M C Mazzilli, E Gandini

HLA-ABC and DR antigens in celiac disease. A study in a pediatric Italian population

S Trabace et al. Vox Sang. 1984.

Abstract

HLA phenotypes of 64 Italian pediatric patients with celiac disease (CD) were compared with those of a group of healthy controls. DR3 and DR7 are significantly increased as reported in other populations. In addition an increase of heterozygotes DR5/DR7 was observed in our patients. The Hardy-Weinberg distribution in the patients group shows a disequilibrium due to the genotype DR5/DR7. Our data confirm that more than one HLA gene product is associated with CD: one with DR3 and the other with DR7.

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