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. 1978 Apr 15;56(8):405-7.
doi: 10.1007/BF01477295.

Nitrofurantoin damages DNA of human cells

M Hirsch-Kauffmann, P Herrlich, M Schweiger

Nitrofurantoin damages DNA of human cells

M Hirsch-Kauffmann et al. Klin Wochenschr. .

Abstract

Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions.

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