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. 1976 Dec;83(12):938-42.
doi: 10.1111/j.1471-0528.1976.tb00779.x.

Sequential studies on components of the haemostatic mechanism in pregnancy with particular reference to the development of pre-eclampsia

R G Condie, D Ogston

Sequential studies on components of the haemostatic mechanism in pregnancy with particular reference to the development of pre-eclampsia

R G Condie et al. Br J Obstet Gynaecol. 1976 Dec.

Abstract

Components of the haemostatic mechanism were studied at intervals in 60 primigravidae over the course of pregnancy and the puerperium; 12 of these developed pre-eclampsia. During pregnancy there was a fall in fibrinolytic activity and fibrinolytic capacity and a rise in fibrinogen, FR-antigen, alpha 1-antitrypsin and alpha 2-macroglobulin. The women who subsequently developed pre-eclampsia could not be identified on the basis of these measurements. Following delivery there was a more rapid return of fibrinolytic activity and capacity towards normal in the women who had not had pre-eclampsia. The urinary FR-antigen level was higher in the women with pre-eclampsia.

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