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. 1984 Apr;51(1):21-9.
doi: 10.1016/0021-9150(84)90141-2.

The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II

S J Hasstedt, J J Albers, M C Cheung, L B Jorde, D E Wilson, C Q Edwards, W N Cannon, K O Ash, R R Williams

The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II

S J Hasstedt et al. Atherosclerosis. 1984 Apr.

Abstract

A large pedigree was ascertained through cases of early myocardial infarction. High density lipoprotein cholesterol and apolipoproteins A-I and A-II were measured on family members. Likelihood analysis, using the polygenic/major gene mixed model, provided no evidence that major loci play a role in determining the levels of any of the three measurements. Heritability estimates, assuming polygenic inheritance, were 0.59 and 0.26 for HDL-C level and A-II level, respectively. No evidence of genetic transmission of A-I level was found.

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