Case Reports
doi: 10.1016/s0046-8177(84)80078-7.
Light-chain glomerulopathy with amyloid-like deposits
- PMID: 6427095
- DOI: 10.1016/s0046-8177(84)80078-7
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Case Reports
Light-chain glomerulopathy with amyloid-like deposits
Hum Pathol.
1984 May.
Abstract
A 40-year-old man with rapidly progressive renal failure was found to have a lobular glomerulonephritis by renal biopsy. Immunofluorescent microscopy showed prominent glomerular deposition of both kappa and lambda light chains but no significant heavy-chain component. Ultrastructurally, electron-dense deposits in the mesangium and capillary basement membranes had a fibrillar appearance indistinguishable from amyloid. This case illustrates a "light-chain glomerulopathy" distinct from previously reported glomerulopathies associated with the deposition of light chains of a single subclass.
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