Immunoglobulin (Gm) markers and alpha 1-antitrypsin (PI) types in rheumatoid arthritis and early onset chronic active hepatitis

Abstract

No Gm allotype, haplotype or phenotype was increased or decreased in frequency in two autoimmune diseases, rheumatoid arthritis (RA) or chronic active hepatitis (CAH) in comparison with control frequencies. The frequencies of the Gm haplotypes among 206 controls were 0.70, 0.19 and 0.11 for fb, ag and axg , respectively. Neither Gm heterozygosity nor homozygosity was associated with either disease. There was no interaction between alpha 1-antitrypsin (PI) and Gm type in the two diseases.