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. 1984;5(4):439-44.
doi: 10.1002/pros.2990050408.

Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor

H W Herr, E L Kleinert

Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor

H W Herr et al. Prostate. 1984.

Abstract

alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats. Neither DFMO (2%) nor MGBG at a nontoxic dose (15 mg/kg) inhibited tumor growth, but total (47% early cure rate) or near total suppression of growth of established tumors was observed in rats receiving both treatments.

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