A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes

Abstract

Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.