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Comparative Study
. 1984 May;47(5):1023-6.
doi: 10.1128/aem.47.5.1023-1026.1984.

Membrane ultrafiltration: concentration of interleukin-3

F Klein, R T Ricketts, T R Rohrer, W I Jones Jr, P M Clark, M C Flickinger
Comparative Study

Membrane ultrafiltration: concentration of interleukin-3

F Klein et al. Appl Environ Microbiol. 1984 May.

Abstract

A pilot-plant-scale operation was used for studying membrane ultrafiltration and concentration of kiloliter quantities of the lymphokine interleukin-3 with a single set of membranes. Initial use of ammonium sulfate precipitation of interleukin-3 proved erratic in the recovery of biological activity and resulted in corrosion of the processing equipment. Membrane ultrafiltration proved to be effective in enabling control of the degree of concentration and predicting recovery of the biologically active protein.

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