doi: 10.1016/0091-3057(84)90125-4.
Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine
- PMID: 6431452
- DOI: 10.1016/0091-3057(84)90125-4
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Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine
Pharmacol Biochem Behav.
1984 Jul.
Abstract
We now report that 6-hydroxydopamine (0.39 +/- 0.31 nanograms/mg of tissue at 2 hr) is formed in the rat caudate nucleus after a single injection of methylamphetamine (100 mg/kg). The same dose of methylamphetamine causes approximately 50% depletion of caudate dopamine 2 weeks after the injection. We suggest that the formation of 6-hydroxydopamine from endogenous dopamine is responsible for the neurotoxicity to dopamine terminals seen after methylamphetamine administration.
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