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Clinical Trial
. 1984;83(2):129-33.
doi: 10.1007/BF00429720.

Amoxapine and amitriptyline. I. Relative speed of antidepressant action

D M McNair, R J Kahn, L M Frankenthaler, L L Faldetta
Clinical Trial

Amoxapine and amitriptyline. I. Relative speed of antidepressant action

D M McNair et al. Psychopharmacology (Berl). 1984.

Abstract

Speed of onset of antidepressant effect was studied in 20 depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline. In counter-balanced order, each patient had 2 periods of 3 weeks on active agent interspersed with 2 similar periods of placebo control. On daily and weekly self-ratings, amoxapine was found to reduce symptoms significantly more rapidly than amitriptyline. Psychiatrist-ratings were consonant with self-reports.

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