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. 1984;83(2):151-4.
doi: 10.1007/BF00429724.

Effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, MK-771, on punished responding of squirrel monkeys

L S Brady, J O Valentine, J E Barrett

Effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, MK-771, on punished responding of squirrel monkeys

L S Brady et al. Psychopharmacology (Berl). 1984.

Abstract

The effects of thyrotropin-releasing hormone (TRH) and an enzyme-resistant analogue, MK-771, were compared on punished responding of squirrel monkeys maintained either by food presentation or stimulus-shock termination. Both TRH and MK-771 (1.0-30 mg/kg IM) produced dose-related decreases in punished responding maintained by food presentation and dose-related increases in punished responding maintained by shock termination. TRH was more potent than MK-771 in altering punished response rates maintained by either event.

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