Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1984 Aug 18;289(6442):400-2.
doi: 10.1136/bmj.289.6442.400.

Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg-Strauss syndrome

P C Tai, M E Holt, P Denny, A R Gibbs, B D Williams, C J Spry
Case Reports

Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg-Strauss syndrome

P C Tai et al. Br Med J (Clin Res Ed). .

Abstract

Biopsy specimens and tissues obtained at necropsy from two women who died after developing the Churg-Strauss syndrome were analysed to see whether granulomas in these patients contained activated eosinophils or secreted eosinophil cationic proteins, or both. Immunocytochemical studies with monoclonal antibody EG2 showed large amounts of eosinophil cationic protein and eosinophil protein-X (which are toxic for heart cells and other tissues) in the granulomas. Many activated and degranulating eosinophils were seen to be migrating from the blood into these areas. Eosinophils may play a central part in the development of lesions in the heart and other tissues in the Churg-Strauss syndrome.

PubMed Disclaimer

References

    1. Am J Pathol. 1951 Mar-Apr;27(2):277-301 - PubMed
    1. Nature. 1984 May 10-16;309(5964):182-4 - PubMed
    1. Thorax. 1983 Oct;38(10):793-5 - PubMed
    1. Q J Med. 1983 Winter;52(205):23-39 - PubMed
    1. Br J Dermatol. 1983 Aug;109(2):141-8 - PubMed

Publication types

LinkOut - more resources