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. 1984 Aug 16;122(3):877-83.
doi: 10.1016/0006-291x(84)91172-0.

The human apolipoprotein A-II gene is located on chromosome 1

K J Lackner, S W Law, H B Brewer Jr, A Y Sakaguchi, S L Naylor

The human apolipoprotein A-II gene is located on chromosome 1

K J Lackner et al. Biochem Biophys Res Commun. .

Abstract

Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21----qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.

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