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. 1984 Oct 19;226(4672):348-9.
doi: 10.1126/science.6435246.

Chromosomal location of human T-cell receptor gene Ti beta

P E Barker, F H Ruddle, H D Royer, O Acuto, E L Reinherz

Chromosomal location of human T-cell receptor gene Ti beta

P E Barker et al. Science. .

Abstract

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

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