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. 1984 Aug;26(2):272-4.
doi: 10.1128/AAC.26.2.272.

Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa

M A Bertram, L S Young

Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa

M A Bertram et al. Antimicrob Agents Chemother. 1984 Aug.

Abstract

The MICs of imipenem and piperacillin, alone and in combination, against Pseudomonas aeruginosa were determined in a checkerboard titration microdilution assay. A dramatic, one-way antagonism of imipenem for piperacillin was demonstrated in 28 of the 35 strains examined; antagonism was associated with the induction of a beta-lactamase.

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References

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