Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;27(1):115-7.

Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man

U Klotz, G Ziegler, I W Reimann
  • PMID: 6436030

Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man

U Klotz et al. Eur J Clin Pharmacol. 1984.

Abstract

The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40 +/- 8%, mean +/- SD). A negligible amount (less than 0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9 +/- 0.2 h, and high total plasma and blood clearances of 691 +/- 216 ml/min and 716 +/- 199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.

PubMed Disclaimer

References

    1. Br J Clin Pharmacol. 1982 Nov;14(5):677-82 - PubMed
    1. Lancet. 1981 Jul 4;2(8236):8-10 - PubMed
    1. Nature. 1981 Apr 9;290(5806):514-6 - PubMed
    1. Psychopharmacology (Berl). 1983;80(2):192-5 - PubMed
    1. Pharmacology. 1983;26(5):285-9 - PubMed

Publication types

LinkOut - more resources