doi: 10.1093/nar/5.1.195.
Two initiation sites for adenovirus 5.5S RNA
- PMID: 643608
- PMCID: PMC341971
- DOI: 10.1093/nar/5.1.195
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Two initiation sites for adenovirus 5.5S RNA
Nucleic Acids Res.
1978 Jan.
Abstract
Adenovirus specific 5.5S RNA is heterogeneous at its 5' terminus. Complete pancreatic RNase digests of the RNA reveal a 5' terminal oligonucleotide (pp)pApGpCp in addition to the major 5' terminal (pp)pGpGpGpCp (1). Both 5' termini are detected early as well as late after adenovirus infection. In isolated nuclei, alpha-amanitin inhibits all 5.5S RNA transcription at a concentration of 200 microgram/ml, indicating that both initiation sites are recognized by RNA polymerase III.
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