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Comparative Study
. 1978 Mar;5(3):951-60.
doi: 10.1093/nar/5.3.951.

Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km

U Kuhnlein, B Lee, E E Penhoet, S Linn
Free PMC article
Comparative Study

Xeroderma pigmentosum fibroblasts of the D group lack an apurinic DNA endonuclease species with a low apparent Km

U Kuhnlein et al. Nucleic Acids Res. 1978 Mar.
Free PMC article

Abstract

Apurinic DNA endonuclease activity from cultured human fibroblasts was resolved into two species by phosphocellulose chromatography. The species had sedimentation coefficients of 3.3 S and 2.8 S and apparent Km's for apurinic sites of 5 and 44 nM, respectively. The low Km species was absent from extracts of cell lines XP5BE, XP6BE and XP7BE of xeroderma pigmentosum complementation group D.

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References

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