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. 1984 Sep;22(9):585-9.
doi: 10.1515/cclm.1984.22.9.585.

Frequency of apolipoprotein A-I mutants in the German population

G Assmann, H J Menzel, R G Kladetzky, G Büttner

Frequency of apolipoprotein A-I mutants in the German population

G Assmann et al. J Clin Chem Clin Biochem. 1984 Sep.

Abstract

A randomly chosen population in the area of Westphalia (West Germany) was screened for apolipoprotein A-I mutants. About 5000 individuals were investigated and compared with a group of 1300 patients who had undergone coronary angiography. Four electrophoretically different apolipoprotein A-I-mutants (named Münster-1 to 4) were discovered. Five non-related probands were observed in the group of the unselected patients and three non-related probands in the group of coronary angiography patients. In most cases the familial nature of the abnormality was confirmed by pedigree analysis.

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