Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Nov;81(21):6733-7.
doi: 10.1073/pnas.81.21.6733.

Transcriptional induction of two genes in human cells by beta interferon

A C Larner, G Jonak, Y S Cheng, B Korant, E Knight, J E Darnell Jr

Transcriptional induction of two genes in human cells by beta interferon

A C Larner et al. Proc Natl Acad Sci U S A. 1984 Nov.

Abstract

The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of beta interferon to human fibroblasts or to HeLa cells. These results prove that a single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. J Biol Chem. 1972 Nov 10;247(21):6970-7 - PubMed
    1. Biochem Biophys Res Commun. 1974 Feb 27;56(4):860-4 - PubMed
    1. Nature. 1979 Jun 7;279(5713):523-5 - PubMed
    1. Nature. 1979 Jun 21;279(5715):679-85 - PubMed

Publication types

LinkOut - more resources