Effect of sustained portal-systemic shunting on glycolytic and citric-acid cycle intermediates in the rat brain
- PMID: 6437831
- DOI: 10.1111/j.1365-2362.1984.tb01192.x
Effect of sustained portal-systemic shunting on glycolytic and citric-acid cycle intermediates in the rat brain
Abstract
The effect of portacaval (PC) shunting on brain glycogen, glucose, glycolytic and citric-acid cycle intermediates was analysed in rats shunted for 3, 8 and 16 weeks. Portal-systemic shunting was accompanied by a progressive fall in brain glucose which was reduced to about half of control after 16 weeks of shunting (P less than 0.05). Glycogen remained unchanged. Glucose-6-phosphate and fructose-1,6-diphosphate were significantly (P less than 0.05) increased and decreased, respectively, which may indicate some inhibition of phosphofructokinase. These changes in brain glucose content and glycolysis may be additive to any further metabolic perturbation and provide one tentative mechanism of sensitization of the brain in liver failure.
Similar articles
-
Brain glucose levels in portacaval-shunted rats with chronic, moderate hyperammonemia: implications for determination of local cerebral glucose utilization.J Cereb Blood Flow Metab. 1994 Jan;14(1):113-24. doi: 10.1038/jcbfm.1994.16. J Cereb Blood Flow Metab. 1994. PMID: 8263046
-
Local cerebral glucose metabolism in rats with chronic portacaval shunts.J Cereb Blood Flow Metab. 1983 Sep;3(3):311-20. doi: 10.1038/jcbfm.1983.46. J Cereb Blood Flow Metab. 1983. PMID: 6874740
-
Cerebral glucose metabolism after portacaval shunting in the rat. Patterns of metabolism and implications for the pathogenesis of hepatic encephalopathy.J Clin Invest. 1986 Jul;78(1):86-95. doi: 10.1172/JCI112578. J Clin Invest. 1986. PMID: 3722388 Free PMC article.
-
Ammonia metabolism in normal and portacaval-shunted rats.Adv Exp Med Biol. 1990;272:23-46. doi: 10.1007/978-1-4684-5826-8_2. Adv Exp Med Biol. 1990. PMID: 2103690 Review.
-
Energy metabolism in the brain.Int Rev Neurobiol. 2002;51:1-102. doi: 10.1016/s0074-7742(02)51003-5. Int Rev Neurobiol. 2002. PMID: 12420357 Review. No abstract available.
Cited by
-
Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.Metab Brain Dis. 2001 Jun;16(1-2):67-78. doi: 10.1023/a:1011666612822. Metab Brain Dis. 2001. PMID: 11726090 Review.
-
Regional blood-brain barrier transport of glucose after portacaval anastomosis.Metab Brain Dis. 1986 Jun;1(2):119-28. doi: 10.1007/BF00999382. Metab Brain Dis. 1986. PMID: 3508237
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
