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. 1984;68(2):165-8.
doi: 10.1007/BF00279308.

Genetic linkage between erythrokeratodermia variabilis and Rh locus

J G van der Schroeff, L E Nijenhuis, P Meera Khan, L F Bernini, G M Schreuder, E van Loghem, W S Volkers, L N Went

Genetic linkage between erythrokeratodermia variabilis and Rh locus

J G van der Schroeff et al. Hum Genet. 1984.

Abstract

A genetic linkage study was performed in a large Dutch kindred with erythrokeratodermia variabilis (EKV, McKusick no. 13320). The autosomal-dominant trait appeared to segregate rather consistently with the cde (r) gene complex of the Rh system. Only one recombinant was found amongst 27 informative individuals. Lod score calculations gave strong evidence for close linkage between the loci for EKV and Rh (with a maximum lod score of 5.55 at a recombination fraction of 0.044).

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