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Comparative Study
. 1984 Nov;312(5992):337-42.
doi: 10.1038/312337a0.

Structure of human factor VIII

G A Vehar, B Keyt, D Eaton, H Rodriguez, D P O'Brien, F Rotblat, H Oppermann, R Keck, W I Wood, R N Harkins, E G Tuddenham, R M Lawn, D J Capon
Comparative Study

Structure of human factor VIII

G A Vehar et al. Nature. 1984 Nov.

Abstract

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

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