Comparative Study
doi: 10.1038/312337a0.
Structure of human factor VIII
- PMID: 6438527
- DOI: 10.1038/312337a0
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Comparative Study
Structure of human factor VIII
Nature.
1984 Nov.
Abstract
The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.
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