Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Nov;312(5992):342-7.
doi: 10.1038/312342a0.

Molecular cloning of a cDNA encoding human antihaemophilic factor

J J Toole, J L Knopf, J M Wozney, L A Sultzman, J L Buecker, D D Pittman, R J Kaufman, E Brown, C Shoemaker, E C Orr, et al.

Molecular cloning of a cDNA encoding human antihaemophilic factor

J J Toole et al. Nature. 1984 Nov.

Abstract

A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources