Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Dec;312(5994):517-20.
doi: 10.1038/312517a0.

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice

K A Ritchie, R L Brinster, U Storb

Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice

K A Ritchie et al. Nature. 1984 Dec.

Abstract

Hybridomas were produced from spleen cells of kappa transgenic mice to investigate expression of the transgenic kappa gene, its effect on allelic exclusion and its effect on the control of light-chain gene rearrangement and expression. Our results show that the transgene is expressed normally and that the production of a complete immunoglobulin molecule turns off light-chain gene rearrangement.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources