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Comparative Study
. 1984 Nov;20(5):923-6.
doi: 10.1128/jcm.20.5.923-926.1984.

Criteria for detection of Clostridium difficile toxin production by counterimmunoelectrophoresis

R P Rennie, J M Elliott, M A Nardini, J H Thornley
Comparative Study

Criteria for detection of Clostridium difficile toxin production by counterimmunoelectrophoresis

R P Rennie et al. J Clin Microbiol. 1984 Nov.

Abstract

Counterimmunoelectrophoresis (CIE) was compared with a cytotoxicity assay and isolation of toxin-producing Clostridium difficile for the diagnosis of antibiotic-associated diarrhea. Standardized criteria for CIE positivity were established as two major precipitin lines with specific C. difficile antitoxin. Using these criteria on 425 fecal specimens, we determined the sensitivity of CIE (80%) to be comparable to that of the cytotoxicity assay (82%). Both methods were highly specific. With carefully controlled techniques, CIE can be used in routine diagnostic laboratories to screen for toxigenic C. difficile.

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References

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