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Clinical Trial
. 1984;84(3):342-6.
doi: 10.1007/BF00555210.

Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations

N Pomara, B Stanley, R Block, J Guido, D Russ, R Berchou, M Stanley, D J Greenblatt, R E Newton, S Gershon
Clinical Trial

Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations

N Pomara et al. Psychopharmacology (Berl). 1984.

Abstract

Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.

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