Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jan 1;151(1):257-62.
doi: 10.1084/jem.151.1.257.

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30)

S Broder, D L Mann, T A Waldmann

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30)

S Broder et al. J Exp Med. .

Abstract

We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.

PubMed Disclaimer

References

    1. J Immunol. 1972 Aug;109(2):304-10 - PubMed
    1. J Exp Med. 1974 Aug 1;140(2):481-93 - PubMed
    1. Adv Immunol. 1975;20:125-95 - PubMed
    1. J Exp Med. 1975 Apr 1;141(4):924-9 - PubMed
    1. Transplant Rev. 1976;30:122-39 - PubMed