Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter
- PMID: 6445512
- DOI: 10.1007/BF00964614
Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter
Abstract
Lipid changes in rat brain grey matter were observed in a coculture system of innervating and target explants. The de novo biosynthesis of individual glycerolipids and the metabolism of fatty acids were investigated. Innervating grey matter cultures exhibited a substantial increase in neutral glycerolipid formation. Only slight modifications were observed in the fatty acid fraction. Target cells responded to innervation by a marked increase in phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine formation. In addition, the biosynthesis of arachidonate and docosahexaenoate was drastically enhanced. It is shown that neuritic bridges connecting the explants, rather than soluble factors, account for the effects observed. Putative mechanisms involved in changes of lipid metabolism are discussed.
Similar articles
-
Metabolism of lipids in rat testes: interconversions and incorporation of linoleic acid into lipid classes.Lipids. 1969 Jan;4(1):41-9. doi: 10.1007/BF02531793. Lipids. 1969. PMID: 5766848 No abstract available.
-
Lipids of cultured hepatoma cells. VI. Glycerolipid and monoenoic fatty acid biosynthesis in minimal deviation hepatoma 7288C-1.Lipids. 1975 Mar;10(3):194-201. doi: 10.1007/BF02534159. Lipids. 1975. PMID: 165343
-
Incorporation of (1-14c)-oleic acid into neutral glycerides and phosphoglycerides of mouse brain.Lipids. 1973 Jul;8(7):410-4. doi: 10.1007/BF02531717. Lipids. 1973. PMID: 4353291 No abstract available.
-
Eukaryotic phospholipid biosynthesis.Annu Rev Biochem. 1995;64:315-43. doi: 10.1146/annurev.bi.64.070195.001531. Annu Rev Biochem. 1995. PMID: 7574485 Review.
-
Microbial lipid metabolism.CRC Crit Rev Microbiol. 1975 Oct;4(1):1-40. doi: 10.3109/10408417509105485. CRC Crit Rev Microbiol. 1975. PMID: 1102257 Review. No abstract available.
Cited by
-
Preparation and Culture of Organotypic Hippocampal Slices for the Analysis of Brain Metastasis and Primary Brain Tumor Growth.Methods Mol Biol. 2021;2294:59-77. doi: 10.1007/978-1-0716-1350-4_5. Methods Mol Biol. 2021. PMID: 33742394
-
Developmental changes in the fatty acids of synaptic membrane phospholipids: effect of protein malnutrition.Neurochem Res. 1981 Sep;6(9):935-47. doi: 10.1007/BF00965025. Neurochem Res. 1981. PMID: 6798482
-
Mature and immature synaptosomal membranes have a different lipid composition.Neurochem Res. 1985 Jan;10(1):133-44. doi: 10.1007/BF00964778. Neurochem Res. 1985. PMID: 3982588