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. 1980 Mar;5(3):257-70.
doi: 10.1007/BF00964614.

Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter

Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter

M Giesing et al. Neurochem Res. 1980 Mar.

Abstract

Lipid changes in rat brain grey matter were observed in a coculture system of innervating and target explants. The de novo biosynthesis of individual glycerolipids and the metabolism of fatty acids were investigated. Innervating grey matter cultures exhibited a substantial increase in neutral glycerolipid formation. Only slight modifications were observed in the fatty acid fraction. Target cells responded to innervation by a marked increase in phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine formation. In addition, the biosynthesis of arachidonate and docosahexaenoate was drastically enhanced. It is shown that neuritic bridges connecting the explants, rather than soluble factors, account for the effects observed. Putative mechanisms involved in changes of lipid metabolism are discussed.

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