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. 1977 Jan;15(1):78-83.
doi: 10.1128/iai.15.1.78-83.1977.

Cellular origin of interferon induced by bacterial lipopolysaccharide

N Maehara, M Ho

Cellular origin of interferon induced by bacterial lipopolysaccharide

N Maehara et al. Infect Immun. 1977 Jan.

Abstract

Bacterial lipopolysaccharide (LPS) induces interferons with different properties in mouse macrophages and B lymphocytes. Macrophage interferon is labile at 56 degrees C and is neutralized by anti-mouse fibroblast interferon at a dilution of 1:6,142. B cell interferon is more heat stable and is neutralized by the same antiserum only at a dilution of 1:276. Serum obtained early (1 h) after an intravenous injection of 100 mug of LPS resembled macrophage interferon, whereas serum obtained at later times resembled more and more B cell interferon. The diverse cellular origin of LPS-induced interferon may explain the broad hyporesponsiveness produced by LPS in animals.

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References

    1. J Immunol. 1975 Jul;115(1):230-3 - PubMed
    1. Science. 1965 Jul 16;149(3681):310-1 - PubMed
    1. Annu Rev Microbiol. 1975;29:131-61 - PubMed
    1. J Exp Med. 1967 Apr 1;125(4):559-77 - PubMed
    1. Proc Soc Exp Biol Med. 1968 Nov;129(2):433-8 - PubMed

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