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. 1980 Jun;17(6):1004-7.
doi: 10.1128/AAC.17.6.1004.

Therapy of obstetrical infections with moxalactam

R S Gibbs, J D Blanco, Y S Castaneda, P J St Clair

Therapy of obstetrical infections with moxalactam

R S Gibbs et al. Antimicrob Agents Chemother. 1980 Jun.

Abstract

We evaluated moxalactam in 62 patients with puerperal or postabortal genital infections. In all patients, the initial dose was 6 g/day. In 84% of patients, we found anaerobes in genital specimens. Of aerobic isolates, only enterococci were resistant. Among anaerobes tested, only two isolates (a Clostridium leptum and a Bacteroides disiens) had minimal inhibitory concentrations of greater than or equal to microgram/ml. Good clinical responses occurred in 56 of 62 (90%). Moxalactam was well tolerated with little local irritation and minimal hepatic, renal, or hematological abnormalities.

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References

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