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. 1980 Oct 15;36(10):1186-7.
doi: 10.1007/BF01976118.

Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats

N Chand, B M Altura

Occurrence of inhibitory histamine H2-receptors in isolated pulmonary blood vessels of dogs and rats

N Chand et al. Experientia. .

Abstract

Isolated, helically cut strips of pulmonary arteries and veins of dogs, and pulmonary arteries of rats, precontracted with norepinephrine or 5-HT exhibited potent concentration-dependent relaxations to impromidine and dimaprit (histamine H2-agonists). The occurrence of inhibitory histamine H2-receptors in the pulmonary vasculature could play a modulatory role in hypoxic pulmonary vasoconstriction.

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