Vanadate inhibition of the Ca++-ATPase of sarcoplasmic reticulum from pig heart
- PMID: 6449926
- DOI: 10.1007/BF01908410
Vanadate inhibition of the Ca++-ATPase of sarcoplasmic reticulum from pig heart
Abstract
Ca++-ATPase of sarcoplasmic reticulum from pig heart can be inhibited by vanadate with half maximal inhibition at about 10(-5)M NH4VO3. At the same time vanadate lowers the [Mg++] for maximal activity of the Ca++-ATPase to half, from 8 X 10(-3)M to 4 X 10(-3)M Mg++. At low vanadate concentrations around 5 X 10(-8)M the Ca++-ATPase was activated.