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. 1981 Jan 1;153(1):213-8.
doi: 10.1084/jem.153.1.213.

Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture

A Moretta, M C Mingari, B F Haynes, R P Sekaly, L Moretta, A S Fauci

Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture

A Moretta et al. J Exp Med. .

Abstract

Mixed lymphocyte reaction (MLR)-activated T cells were analyzed according to the expression of various cell surface markers by the specific cytotoxic T lymphocytes (CTL) generated in the MLR. CTL were found exclusively in a population of MLR-activated T cells that lacked detectable Fc gamma R but that expressed a surface antigen recognized by the 4F2 monoclonal antibody. In contrast, CTL were found in both the Ia-positive and Ia-negative cells after MLR activation. Thus, the specific CTL generated in the allogeneic MLR can be identified and isolated by virtue of the expression of a particular cell surface marker.

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