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. 1981 Jan;42(1):1-6.

Thymus-dependent lymphocytes of dengue virus-infected mice spleens mediate suppression through prostaglandin

U C Chaturvedi, M I Shukla, A Mathur

Thymus-dependent lymphocytes of dengue virus-infected mice spleens mediate suppression through prostaglandin

U C Chaturvedi et al. Immunology. 1981 Jan.

Abstract

Our earlier observations indicate that adoptive transfer of spleen cells obtained from dengue type 2 virus (DV)-primed mice suppressed DV antigen-specific antibody secretion as detected by Jerne PFC technique. Findings of this paper indicate that the suppression was produced by non-glass-adherent cells, macrophage-depleted (by carbonyl iron) cells and by T lymphocytes of the spleen but not by the glass-adherent cells and B lymphocytes. The activity of these cells is dependent upon production of prostaglandin as shown by abrogation of their suppressor activity by pre-treatment of cells by indomethacin or aspirin which are known to block synthesis of prostaglandins.

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