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. 1978 Feb;57(2):180-5.
doi: 10.1111/j.1600-0404.1978.tb02835.x.

Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine

B Johansson

Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine

B Johansson. Acta Neurol Scand. 1978 Feb.

Abstract

Amphetamine productes protein leakage in the brain when given to rats under nitrous oxide anesthesia. The blood-brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg.kg-1, diminished the amphetamine-induced extravasation of Evans blue albumin and 125IHSA in the rats' brain. Possible explanations to the effect of dexamethasone on cerebrovascular permeability are discussed.

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