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Case Reports
. 1981 Oct 15;48(8):1922-5.
doi: 10.1002/1097-0142(19811015)48:8<1922::aid-cncr2820480833>3.0.co;2-2.

Parenteral diphosphonates for treating malignant hypercalcemia

A Jung, C van Ouwenaller, A Chantraine, B Courvoisier
Case Reports

Parenteral diphosphonates for treating malignant hypercalcemia

A Jung et al. Cancer. .

Abstract

Two diphosphonates, EHDP (disodium etidronate, or ethanehydroxy-diphosphonate) and Cl2MDP (disodium clodronate, or dichloromethylene-diphosphonate) were injected in various doses in six patients with one or multiple episodes of malignant hypercalcemia. All patients responded well to the drugs after a delay period of two to seven days. The tolerance of the drugs was excellent. EHDP, and especially Cl2MDP, are promising agents for treating hypercalcemia and inhibiting bone resorption in malignant disorders.

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