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. 1981 Aug;57(670):479-81.
doi: 10.1136/pgmj.57.670.479.

Platelet monoamine uptake in relatives of patients with Huntington's chorea

R S Ehsanullah, P Turner

Platelet monoamine uptake in relatives of patients with Huntington's chorea

R S Ehsanullah et al. Postgrad Med J. 1981 Aug.

Abstract

Uptake of dopamine and 5-hydroxytryptamine (5-HT) by the platelets of 25 symptom-free relatives of patients with established Huntington's chorea (HC) was not significantly different from that of control subjects. Platelet uptake of 5-HT in 3 subjects with early signs of the disease showed increased Km and Vmax values. Increased platelet uptake of 5-HT in patients with established HC was confirmed in a further 3 patients. It seems that this phenomenon appears with the clinical evidence of the disease. Further investigation of the nature of the platelet uptake abnormality may cast light on pathogenic factors in HC.

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