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Case Reports
. 1978 Mar;27(2 Pt 1):360-2.
doi: 10.4269/ajtmh.1978.27.360.

Seizures and electroencephalograph changes associated with oxamniquine therapy

J S Keystone
Case Reports

Seizures and electroencephalograph changes associated with oxamniquine therapy

J S Keystone. Am J Trop Med Hyg. 1978 Mar.

Abstract

A Tanzanian man with a known seizure disorder was admitted to hospital for treatment of schistosomiasis mansoni. He suffered a grand mal seizure soon after the second dose of oxamniquine. This is the first recorded seizured associated with use of this drug. Two other cases are reported in which transient electroencephalograph changes occurred during oxamniquine therapy. The central nervous system effects of oxamniquine are reviewed with respect to its possible epileptogenic effects.

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