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Clinical Trial
. 1982 Apr;6(4 Pt 2 Suppl):760-5.
doi: 10.1016/s0190-9622(82)70066-0.

Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion

J A Goldstein, A Socha-Szott, R J Thomsen, P E Pochi, A R Shalita, J S Strauss
Clinical Trial

Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion

J A Goldstein et al. J Am Acad Dermatol. 1982 Apr.

Abstract

Isotretinoin (13-cis-retinoic acid) was compared with the aromatic retinoid, etretinate, in patients with severe nodulocystic acne. Evaluation of fifty-six such men receiving 1 mg/kg of one or the other of these two drugs was performed with regard to clinical improvement and change in sebum production. Lesion counting demonstrated a significant improvement in patients receiving isotretinoin, particularly in facial lesions. There was significantly less improvement with etretinate. Similarly, isotretinoin produced a marked suppression of sebum production. There was little effect of etretinate on sebum production. Side effects were limited primarily to the skin and mucous membranes.

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