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. 1984 Aug;310(5977):469-75.
doi: 10.1038/310469a0.

Malignant transformation of early passage rodent cells by a single mutated human oncogene

D A Spandidos, N M Wilkie

Malignant transformation of early passage rodent cells by a single mutated human oncogene

D A Spandidos et al. Nature. 1984 Aug.

Abstract

When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal Ha-ras-1 proto-oncogene only induces immortalization. Therefore, mutated Ha-ras-1 does not require a cooperating gene to trigger malignant conversion and ras genes may be involved in the process of tumorigenesis at an earlier stage than previously suspected.

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