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. 1984 Jul 25;12(14):5869-77.
doi: 10.1093/nar/12.14.5869.

Increased G + C content of DNA stabilizes methyl CpG dinucleotides

R L Adams, R Eason
Free PMC article

Increased G + C content of DNA stabilizes methyl CpG dinucleotides

R L Adams et al. Nucleic Acids Res. .
Free PMC article

Abstract

The vertebrate genome is a mosaic of regions differing dramatically in their G + C content. Those regions with a high G + C content contain the expected number of CpG dinucleotides and we propose that following methylation these have been protected from deamination by the increased stability of the surrounding DNA duplex. This argument applies both to the microenvironment of the CpG dinucleotide and to whole gene regions.

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