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. 1984 Aug 17;225(4663):718-21.
doi: 10.1126/science.6463648.

Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene

H Persson, P Leder

Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene

H Persson et al. Science. .

Abstract

Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.

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