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Comparative Study
. 1984 Jul;317(1):125-8.
doi: 10.1016/0165-3806(84)90147-0.

Characterization of penicillin- and bicuculline-induced epileptiform discharges during development of striate cortex in rabbits

B G Campbell, L H Ostrach, J W Crabtree, K L Chow
Comparative Study

Characterization of penicillin- and bicuculline-induced epileptiform discharges during development of striate cortex in rabbits

B G Campbell et al. Brain Res. 1984 Jul.

Abstract

A comparison was made between penicillin- and bicuculline-induced epileptiform activity. Aqueous solutions of either penicillin or bicuculline were applied to striate cortex of rabbit pups, and the electroencephalogram was monitored. Applications were made twice daily for 14 consecutive days beginning on postnatal day 8-9. During this time period, interictal spikes generated by bicuculline and penicillin displayed similar properties in most respects. However, the morphology of spikes induced by each convulsant was different.

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